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    <lastmod>2026-01-06</lastmod>
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  <url>
    <loc>https://www.opreskolab.com/research</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2020-05-04</lastmod>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e7904a19ba0607a8f2f5374/1588379040377-JUA19FZU50NBNJMTG08F/chromosome%252Bfusions%252Bwebsite%252Bcrop2.jpg</image:loc>
      <image:title>Research - Our Mission.</image:title>
      <image:caption>Telomeres shorten naturally with age, but genetic and environmental factors can accelerate telomere loss. Critically short telomeres contribute to cancer and aging-related diseases. We aim to understand how DNA damage at telomeres impacts their function, and whether or how the damage is repaired.</image:caption>
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      <image:title>Research - Research Interests.</image:title>
      <image:caption>Telomeres are highly susceptible to damage caused by oxidative and genotoxic stress arising from free radicals, DNA damaging agents including sunlight, and inflammation. Key broad questions we are addressing: How does oxidative and genotoxic stress accelerate telomere shortening and dysfunction? What are the cellular pathways that preserve telomeres in the face of DNA damage? What are the consequences of telomere damage on telomere integrity, overall genome stability, cellular function, and organism health?</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e7904a19ba0607a8f2f5374/1588386497880-980I1J2QNAWZDAZXXE6W/Slide2.png</image:loc>
      <image:title>Research</image:title>
      <image:caption>FAP peptides binds photosensitizer dye (MG) at telomeres. Red light produces 8-oxoguanine, a common form of oxidative DNA damage.</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e7904a19ba0607a8f2f5374/1588449964235-EOACJRI6DPGAO708ZHSF/Slide3.jpg</image:loc>
      <image:title>Research</image:title>
      <image:caption>AKTA Pure FPLC system for protein purification. Schematic of telomerase mediated telomere lengthening. Products from telomerase reactions.</image:caption>
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    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5e7904a19ba0607a8f2f5374/1588438683002-2ZYAK3CV4PYM9VXCDW1N/Slide4.jpg</image:loc>
      <image:title>Research</image:title>
      <image:caption>Schematic of base excision repair pathways at telomeres.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.opreskolab.com/links</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2024-11-22</lastmod>
  </url>
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